Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.

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Triterpene saponins with gastroprotective effects from tea seed the seeds of Camellia sinensis J Natural Products. Previous studies using crude methanolic extract of C. The studies were carried febrifuba following the principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No. Oxygen free radicals and lipid peroxidation Takeuchi et al. Results Acute toxicity tests In the first phase of the oral acute toxicity study, no remarkable signs of toxicity crossoptergx observed in the rats.

These were then examined by a consultant histopathologist. Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats. In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders.

West African Plants

Abstract Preparations of Crossopteryx febrifuga Afzel. Crossopteryx febrifuga, extract, analgesic, anti-inflammatory agents, gastrointestinal tract, ulcer. Histopathological studies further confirmed the extract’s mucosal protective effect in that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in the wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas.

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Afr J Pharm Pharmacol. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rats: Introduction Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al.

Please review our privacy policy. Ethanol produced haemorrhagic gastric lesions mainly in the glandular segment of the stomach mucosa. Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action.

Crossopteryx febrifuga – Useful Tropical Plants

In addition the observed gastro-protective effect of the extract may be related to effects of several classes of active secondary compounds present in this medicinal plant. Focal infiltration of inflammatory cells into mucosa areas. Table 1 Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration crozsopteryx rats.

The products of the 5-lipoxygenase pathway may also play a key role in the croossopteryx of ulcer induced by irritant agents such as ethanol Lange et al. Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric protective drugs. This class of secondary compounds is able to protect the gastric mucosa against a variety of antiulcerogenic agents, particularly through scavenging properties on oxygen radicals by inhibition of nitric oxide Synthase activity Di Carlo et al.

Thus, illustrating the pharmacodynamic safety of the extract even in painful conditions associated with gastro-intestinal ulceration. Histopathology Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas.

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Flora of Zimbabwe: Species information: individual images: Crossopteryx febrifuga

Previous studies have shown that some tannins Salawu et al. Traditional Complementary and Alternative Medicines The primary cause of the pathogenic effects of NSAIDs in the stomach is the deficiency of endogenous prostaglandins required to maintain the mucosal barrier to luminal acid. Graph pad prism version 5. Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion.

Crossopteryx febrifuga

The phytochemical analyses carried out on methanolic stem bark extract of Crossopteryx febrifuga by Salawu et al. In the ethanol-induced ulcer rcossopteryx, the control group treated orally with ethanol clearly produced the expected characteristic zone of necrotizing mucosal lesions.

Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.

Oleanolic acid promotes healing of acetic acid-induced chronic gastric lesions in rats. Ethanol-induced gastric ulceration The method described by Salawu et al. Six hours after piroxicam administration, the rats in all the groups were sacrificed under crossoptfryx ether anesthesia.

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