In contrast, the Dissocubes® technology employs piston-gap homogenizers. The technology was developed by Müller and colleagues (, ) and later. DissoCubes are part of Nanosuspension preparation. In which piston–gap high- pressure homogenization occurs. The main advantages of this technology. Employing piston-gap homogenizers, Müller and coworkers developed the Dissocubes technology (now belonging to Skyepharma plc) and the.

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Consequently, at hechnology temperature water starts boiling creating gas bubbles. Piston-Gap Homogenization When the piston-gap HPH technique is employed, the particle size reduction is achieved by cavitation, shear forces and particle collision.

This phenomenon results in the formation of gas bubbles that implode after leaving the gap cavitation. Additionally, as the lyophilization step eliminates the organic solvent content, the subsequently produced nanosuspensions are ready to be further processed or used. Indexed in Web of Science. Preparation and characterization of solid dispersions of itraconazole by using aerosol solvent extraction system for improvement in drug solubility and bioavailability.

It is clearly ideally suited for drugs with solubility problems. To obtain the solution a protective colloid is added. Par Pharmaceutical Companies, Inc.

Thymectacin is poorly soluble and thus needs to be formulated as nanocrystals to become bioavailable. The principles of these methods are described in detail and their merits and demerits are shown in Table 1. An additional effect can be achieved by a controlled structural change in drug nanoparticles, which means reducing the crystallinity and increasing the amorphous fraction.


An increased awareness in patients not willing to suffer from unnecessary side effects will lead to an increased number of products using nanocrystals to reduce these risks.

DissoCubes: A Novel Formulation to Enhance SolubilityPharma Research Library | Pharma Info Index

Dissocubes technology was developed by Muller in Ultra-long duration local anesthesia produced by injection of lecithin-coated tetracaine microcrystals.

Amorphous drug nanoparticles possess a higher saturation solubility compared to equally sized drug nanocrystals in the crystalline state. In cardiology SLR is used because of its antiproliferative effect to avoid a reoccurring constriction restenosis caused technplogy a hyperplasia of the inner vascular after implantation of a stent into the vessels around the heart.

The oral single dose of Rapamune is 1 or 2 mg, the total tablet weight being approximately mg for 1 mg formulation and approximately.

Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. In many cases a too-fast dissolution tecnhology not desired creation of high plasma peaks, reduction of t max.

Nanosuspension Technologies for Delivery of Poorly Soluble Drugs

Basic principle of high pressure homogenization using a piston gap homogenizer. Adopted from [ 44 ].

Nitrendipine suffered no substantial crystallinity change after the process [ 33 ]. In this manner, it is possible to reduce the energy input and the wearing of the machines [ 6 ].

Nanosuspensions are also used to control infections.

He stated that technoolgy drug in the form of nanosuspension had EC 50 of 0. The drugs were separately dissolved in NMP and then precipitated by adding distilled water.

DissoCubes: A Novel Formulation to Enhance Solubility

This will be an important part of the work for the nanoparticles in future. Nil Conflict of Interest: The drug solution is then frozen e. Results of dose-escalating studies under fed and fasting conditions. However, this technology has a set of drawbacks.


It can be concluded that the size matters regarding the increase in saturation solubility and consequently the increase in dissolution velocity caused by a higher c s. However, they have drawbacks, such as long processing times and the necessity of employing a micronized drug as the starting material [ 2 ].

Anderson de la Llana et al. This means it contains a very low percentage of its total weight as nanocrystals. Then, the drug particles are reduced in size and transformed to the gechnology stable crystalline state after employing a high-energy annealing step, such as high pressure homogenization [ 2425 ].

The other technologies are focused on nanosizing for dissolution rate improvement for oral administration or formulation for topical administration. The drug is dissolved in an organic dissocubbes which is miscible with water and forms the organic phase. J Pharm Biomed Anal. Support Center Support Center. This approach is called top-down, as the size of already existing particles is decreased [ 4 ].

Furthermore, nanocrystals allow for a fast action onset, as the drug is absorbed quickly due to the fast dissolution of the nanoparticles. The factors influencing the particle size reduction effectiveness tehnology the porosity and the diwsocubes of the drug powders. View at Google Scholar A.

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